Tissue engineering of small intestinal tissue using collagen sponge scaffolds seeded with smooth muscle cells.

@article{Nakase2006TissueEO,
  title={Tissue engineering of small intestinal tissue using collagen sponge scaffolds seeded with smooth muscle cells.},
  author={Yuen Nakase and Akeo Hagiwara and Tatsuo Nakamura and S. F. L. Kin and Susumu Nakashima and Tetsuji Yoshikawa and Ken-ichirou Fukuda and Yoshiaki Kuriu and Kouji Miyagawa and Chohei Sakakura and Eigo Otsuji and Yasuhiko Shimizu and Yoshihito Ikada and Hisakazu Yamagishi},
  journal={Tissue engineering},
  year={2006},
  volume={12 2},
  pages={403-12}
}
In a previously reported attempt to regenerate small intestine with autologous tissues, collagen scaffolds were used without cell seeding or with autologous mesenchymal stem cell seeding. However the regenerated intestine lacked a smooth muscle layer. To accomplish regeneration of a smooth muscle layer, this present study used collagen scaffolds seeded with the smooth muscle cells (SMC) in a canine model. Autologous SMC were isolated from stomach wall and cultured. Two types of scaffolds were… CONTINUE READING

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