Tissue engineering of small caliber vascular grafts.

  title={Tissue engineering of small caliber vascular grafts.},
  author={Simon P Hoerstrup and Gregor Z{\"u}nd and Ralf Sodian and Andre Schnell and J{\"u}rg Gr{\"u}nenfelder and Marko Ivan Turina},
  journal={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  volume={20 1},
OBJECTIVE Previous tissue engineering approaches to create small caliber vascular grafts have been limited by the structural and mechanical immaturity of the constructs. This study uses a novel in vitro pulse duplicator system providing a 'biomimetic' environment during tissue formation to yield more mature, implantable vascular grafts. METHODS Vascular grafts (I.D. 0.5 cm) were fabricated from novel bioabsorbable polymers (polyglycolic-acid/poly-4-hydroxybutyrate) and sequentially seeded… CONTINUE READING


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