Tissue engineering of perfused microvessels.

  title={Tissue engineering of perfused microvessels.},
  author={Thomas Neumann and Brian Nicholson and Joan E. Sanders},
  journal={Microvascular research},
  volume={66 1},
One major obstacle toward the creation and survival of larger, three-dimensional tissues is the lack of a vascular network that provides transport of oxygen, nutrients, and metabolic byproducts. Although attempts to create microvasculature in vitro have been described previously (Microcirculation 2 (1995), 377; Tissue Eng. 6 (2000), 105; Ann. NY Accd. Sci. 944 (2001), 443), these methods depend on vascularization of void spaces within the tissue-construct or on the utilization of empty… CONTINUE READING