Tissue engineering of an auricular cartilage model utilizing cultured chondrocyte-poly(L-lactide-epsilon-caprolactone) scaffolds.

@article{Isogai2004TissueEO,
  title={Tissue engineering of an auricular cartilage model utilizing cultured chondrocyte-poly(L-lactide-epsilon-caprolactone) scaffolds.},
  author={Noritaka Isogai and Shinichi Asamura and Tsuyashi Higashi and Yoshito Ikada and Shinichiro Morita and Jeniffer Hillyer and Robin Jacquet and William J. Landis},
  journal={Tissue engineering},
  year={2004},
  volume={10 5-6},
  pages={673-87}
}
To determine the potential development in vivo of tissue-engineered auricular cartilage, chondrocytes from articular cartilage of bovine forelimb joints were seeded on poly(L-lactic acid-epsilon-caprolactone) copolymer scaffolds molded into the shape of a human ear. Copolymer scaffolds alone in the same shape were studied for comparison. Chondrocyte-seeded copolymer constructs and scaffolds alone were each implanted in dorsal skin flaps of athymic mice for up to 40 weeks. Retrieved specimens… CONTINUE READING
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