Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: a porcine model assessed at 18, 24, and 36 weeks.

@article{Chang2006TissueEC,
  title={Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: a porcine model assessed at 18, 24, and 36 weeks.},
  author={Chih-Hung Chang and Tsung-li Kuo and Chien-Cheng Lin and Cheng-Hung Chou and Kuang-Ho Chen and Feng-huei Lin and Hui. Liu},
  journal={Biomaterials},
  year={2006},
  volume={27 9},
  pages={
          1876-88
        }
}
We previously showed that cartilage tissue can be engineered in vitro with porcine chondrocytes and gelatin/chondoitin-6-sulfate/hyaluronan tri-copolymer which mimic natural cartilage matrix for use as a scaffold. In this animal study, 15 miniature pigs were used in a randomized control study to compare tissue engineering with allogenous chondrocytes, autogenous osteochondral (OC) transplantation, and spontaneous repair for OC articular defects. In another study, 6 pigs were used as external… CONTINUE READING

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Animal models for cartilage reconstruction

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