Tissue engineering auricular reconstruction: in vitro and in vivo studies.

@article{Shieh2004TissueEA,
  title={Tissue engineering auricular reconstruction: in vitro and in vivo studies.},
  author={S. J. Shieh and Shinichi Terada and Joseph Phillip Vacanti},
  journal={Biomaterials},
  year={2004},
  volume={25 9},
  pages={1545-57}
}
Although investigators have demonstrated that neocartilage can be constituted in a predetermined shape and in complex three-dimensional structures, such as a human ear, by using cell transplantation on polymer constructs, many unsolved problems still remain. The crucial issues for auricular tissue engineering consisted of optimal cell culture environment, choice of polymers, behavior of chondrocytes, study of cell-polymer constructs in an acceptable animal model, and long-term structural… CONTINUE READING

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