Tissue-engineered vascular grafts created from human induced pluripotent stem cells.

@article{Sundaram2014TissueengineeredVG,
  title={Tissue-engineered vascular grafts created from human induced pluripotent stem cells.},
  author={Sumati Sundaram and Jennifer One and Joshua Siewert and Stephan Teodosescu and Liping Zhao and Sashka Dimitrievska and Hong Qian and Angela Hai Huang and Laura E. Niklason},
  journal={Stem cells translational medicine},
  year={2014},
  volume={3 12},
  pages={1535-43}
}
The utility of human induced pluripotent stem cells (hiPSCs) to create tissue-engineered vascular grafts was evaluated in this study. hiPSC lines were first induced into a mesenchymal lineage via a neural crest intermediate using a serum-free, chemically defined differentiation scheme. Derived cells exhibited commonly known mesenchymal markers (CD90, CD105, and CD73 and negative marker CD45) and were shown to differentiate into several mesenchymal lineages (osteogenic, chondrogenic, and… CONTINUE READING
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