Tissue-engineered trachea regeneration using decellularized trachea matrix treated with laser micropore technique.

@article{Xu2017TissueengineeredTR,
  title={Tissue-engineered trachea regeneration using decellularized trachea matrix treated with laser micropore technique.},
  author={Yong Xu and Dan Li and Zongqi Yin and Aijuan He and Miaomiao Lin and Gening Jiang and Xiao Song and Xuefei Hu and Yi Liu and Jinpeng Wang and Xiaoyun Wang and Liang Duan and Guangdong Zhou},
  journal={Acta biomaterialia},
  year={2017},
  volume={58},
  pages={
          113-121
        }
}
Tissue-engineered trachea provides a promising approach for reconstruction of long segmental tracheal defects. However, a lack of ideal biodegradable scaffolds greatly restricts its clinical translation. Decellularized trachea matrix (DTM) is considered a proper scaffold for trachea cartilage regeneration owing to natural tubular structure, cartilage matrix components, and biodegradability. However, cell residual and low porosity of DTM easily result in immunogenicity and incomplete cartilage… CONTINUE READING

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