Tissue-engineered fibrin scaffolds containing neural progenitors enhance functional recovery in a subacute model of SCI.

@article{Johnson2010TissueengineeredFS,
  title={Tissue-engineered fibrin scaffolds containing neural progenitors enhance functional recovery in a subacute model of SCI.},
  author={Philip James Johnson and Alexander M. Tatara and Dylan A. McCreedy and Alicia D Shiu and Shelly E Sakiyama-Elbert},
  journal={Soft matter},
  year={2010},
  volume={6 20},
  pages={5127-5137}
}
Two recurring problems with stem/neural progenitor cell (NPC) transplantation therapies for spinal cord injury (SCI) are poor cell survival and uncontrolled cell differentiation. The current study evaluated the viability and differentiation of embryonic stem cell-derived neural progenitor cells (ESNPCs) transplanted within fibrin scaffolds containing growth factors (GFs) and a heparin-binding delivery system (HBDS) to enhance cell survival and direct differentiation into neurons. Mouse ESNPCs… CONTINUE READING