Tissue-engineered bone serves as a target for metastasis of human breast cancer in a mouse model.

@article{Moreau2007TissueengineeredBS,
  title={Tissue-engineered bone serves as a target for metastasis of human breast cancer in a mouse model.},
  author={Jodie E Moreau and Kristen Anderson and Joshua R Mauney and Trang Nguyen and David L Kaplan and Michael Rosenblatt},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={10304-8}
}
The high frequency and mortality associated with breast cancer metastasis to bone has motivated efforts to elucidate tumor-stroma interactions in the bone microenvironment contributing to invasion and proliferation of metastatic cells. The development of engineered tissues has prompted the integration of engineered bone scaffolds into animal models as potential targets for metastatic spread. Silk scaffolds were coupled with bone morphogenetic protein-2 (BMP-2), seeded with bone marrow stromal… CONTINUE READING
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