Tissue electrolyte changes induced by high doses of diuretics in rats.

@article{Borchgrevink1987TissueEC,
  title={Tissue electrolyte changes induced by high doses of diuretics in rats.},
  author={Petter Christian Borchgrevink and T A Holten and Per Jynge},
  journal={Pharmacology & toxicology},
  year={1987},
  volume={60 2},
  pages={77-80}
}
High doses of furosemide administered orally to growing rats for 4 weeks induced a pronounced fall in the concentration of magnesium and potassium in plasma, of magnesium in bone and potassium in skeletal muscle, but did not cause any reduction of these ions in the myocardium. The only electrolyte change in the heart of furosemide exposed rats was a higher… CONTINUE READING