Tissue distribution profiles of three antiparkinsonian alkaloids from Piper longum L. in rats determined by liquid chromatography-tandem mass spectrometry.

@article{Liu2013TissueDP,
  title={Tissue distribution profiles of three antiparkinsonian alkaloids from Piper longum L. in rats determined by liquid chromatography-tandem mass spectrometry.},
  author={Haolong Liu and Rong Luo and Xiao-qing Chen and Junhui Liu and Ying Zuo Bi and Li Zheng and Xia Wu},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2013},
  volume={928},
  pages={78-82}
}
The alkaloids of Piper longum L. (PLA) improved motor dysfunction and dopamine depletion in a rat model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. A rapid, accurate, simple, and high-performance liquid chromatography-mass spectrometry method was developed and fully validated to simultaneously detect three P. longum L. antiparkinsonian alkaloids (piperine (PPR), piperlonguminine (PPL), and Δα,β-dihydropiperlonguminine (DPPL)) in rat plasma, heart, liver… CONTINUE READING

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