Tissue distribution of tramadol and metabolites in an overdose fatality.

  title={Tissue distribution of tramadol and metabolites in an overdose fatality.},
  author={Kimberly Ann Moore and Stephen J Cina and Robert H. Jones and Dena M. Selby and Barry Levine and Michael L. Smith},
  journal={The American journal of forensic medicine and pathology},
  volume={20 1},
Tramadol (Ultram) is a centrally acting, synthetic analgesic agent. Although it has some affinity for the opiate receptors, tramadol is believed to exert its analgesic effect by inhibiting the re-uptake of norepinephrine and serotonin. There are several published cases of tramadol's involvement in drug-related deaths and impairment. Reports of deaths involving tramadol alone with associated tissue concentrations are rare. This report documents a case in which tramadol overdose was identified as… CONTINUE READING


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