Tissue distribution of synthetic heme analogues: studies with tin, chromium, and zinc mesoporphyrins.

@article{Bundock1996TissueDO,
  title={Tissue distribution of synthetic heme analogues: studies with tin, chromium, and zinc mesoporphyrins.},
  author={Elizabeth A Bundock and G. S. Drummond and A. Kappas},
  journal={Pharmacology},
  year={1996},
  volume={52 3},
  pages={187-98}
}
The uptake in tissue of Sn-mesoporphyrin (SnMP), Cr-mesoporphyrin (CrMP) and Zn-mesoporphyrin (ZnMP) administered at doses ranging from 1 to 10 mu mol/kg BW and the effects of these compounds on heme oxygenase activity were examined in both adult and neonatal rats. SnMP and CrMP, but not ZnMP, were rapidly cleared from blood and taken up by liver, spleen and kidney where marked inhibition of heme oxygenase activity was demonstrated. None of the metalloporphyrins were detectable in brain, and no… CONTINUE READING