Tissue distribution of radioactivity in rats given tritiated analogues of hepatotoxic pyrrolizidine alkaloids.

@article{Mattocks1977TissueDO,
  title={Tissue distribution of radioactivity in rats given tritiated analogues of hepatotoxic pyrrolizidine alkaloids.},
  author={A. R. Mattocks},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1977},
  volume={7 11},
  pages={665-70}
}
  • A. R. Mattocks
  • Published 1977 in
    Xenobiotica; the fate of foreign compounds in…
1. [3H]Retronecine 7,9-bis-N-ethylcarbamate (RC) given intravenously (120 mg/kg) to male rats showed similar tissue distribution of radioactivity to that after an equally hepatotoxic dose (40 mg/kg) of [3H]synthanecine A bis-N-ethylcarbamate (SAC), but the 3H in most tissues after 3H-SAC was about double that after 3H-RC. 2. Concentrations of radioactivity were initially highest in liver and lung, but were higher in lung after 3H-RC than after 3H-SAC, reflecting the higher pneumotoxicity of the… CONTINUE READING