Tissue distribution of lignans in rats in response to diet, dose-response, and competition with isoflavones.

  title={Tissue distribution of lignans in rats in response to diet, dose-response, and competition with isoflavones.},
  author={Timothy F. Murray and Jinguo Kang and Lee B. Astheimer and William Evan Price},
  journal={Journal of agricultural and food chemistry},
  volume={55 12},
This paper investigates the occurrence and distribution of the lignan metabolites enterodiol (END) and enterolactone (ENL) and the isoflavone daidzein (DAID) in rat tissues by use of liquid chromatography-electrospray ionization mass spectrometry (LC-ESI/MSn) following a variety of dietary regimes. Furthermore, we examined the dose-response and distribution of END and ENL in liver, testes, prostate, and lung, and we investigated the effects of competition between lignans and isoflavones on… 
Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats.
Administration of the flaxseed lignans SDG, SECO and ED demonstrated a high systemic clearance, a large volume of distribution and short half-lives, whereas administration of EL killed the rats within a few hours of dosing, precluding a PK analysis of this lignan.
Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans.
It is shown it is first hydrolyzed and then metabolized in a time-dependent sequence to secoisolariciresinol, enterodiol and ultimately enterolactone, and these metabolites are efficiently absorbed.
A combination of metabolite profiling and network pharmacology to explore the potential pharmacological changes of secoisolariciresinol-diglycoside
An integrated strategy based on metabolite profiling and network pharmacology was applied to explore the metabolism feature and functional changes of Secoisolariciresinol-diglycoside and provided a new insight for exploring the mechanism and therapy indications of drugs.
Availability of bioactive flax lignan from foods and supplements.
The metabolism and efficacies of flaxseed-derived enriched SDG and SDG polymer will be discussed.
Oral Pharmacokinetics of Enriched Secoisolariciresinol Diglucoside and Its Polymer in Rats.
A similar pharmacokinetic profile between the enriched and polymer form of SDG is suggested, providing support for the use ofSDG polymer as a more economical precursor for SECO, ED, and EL in applications of chronic disease management.
A single dose of enterolactone activates estrogen signaling and regulates expression of circadian clock genes in mice.
It is concluded that EL activates estrogen signaling in both male and female mice and that the transient responses may be due to the fast metabolism of the compound.
Pharmacokinetics of Flaxseed Lignans in the Rat
This research aimed to develop and validate an HPLC method with fluorescence detection suitable for pharmacokinetic applications for SECO, ED, and EL quantification in rat serum and indicated that SECO is present in systemic rats.
Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
The consolidation of the considerable body of data on the diverse targets of the lignans will aid continued research into their potential for use in combination with other cancer chemotherapies, utilizing flaxseed lignan-enriched natural products.
Quantitative aspects of the metabolism of lignans in pigs fed fibre-enriched rye and wheat bread
It is suggested that interconversion of plant lignans during digestion and enterohepatic circulation occur without complete conversion to enterolignans, and the importance and implications of systemic exposure to plant lIGNans remain to be elucidated.