Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.

  title={Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.},
  author={Egwin J C Yeo and Conrad Wagner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 1},
Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC is a major protein in rat liver that binds 5-methyltetrahydrofolate polyglutamate in vivo. This enzyme is believed to function in the regulation of the availability of S-adenosylmethionine, the primary donor of methyl groups in the body. The distribution of GNMT in a variety of rat tissues was examined immunohistochemically. In liver, GNMT was most abundant in the periportal region, whereas in… CONTINUE READING
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