Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps).

@article{Cheng2005TissueDA,
  title={Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps).},
  author={Xingguo Cheng and Jonathan M. Maher and Chuan Zhong Chen and Curtis Dean Klaassen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 7},
  pages={
          1062-73
        }
}
Organic anion-transporting polypeptides (Oatps) are Na(+)-independent solute carriers for cellular uptake of organic compounds. The purpose of this study is to determine 1) the constitutive mRNA expression of the 15 mouse Oatp genes in 12 tissues, 2) whether there are gender differences in Oatp expression, and 3) the ontogenic expression of Oatps in liver and kidney. The mRNA expression of the 15 mouse Oatps was quantified using the branched DNA technique. Oatp1a1, 1a4, 1b2, and 2b1 are… CONTINUE READING

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