Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice.

@article{Creek1997TissueDA,
  title={Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice.},
  author={Moire R Creek and Chitra Mani and John S. Vogel and Kenneth W. Turteltaub},
  journal={Carcinogenesis},
  year={1997},
  volume={18 12},
  pages={2421-7}
}
The tissue distribution and macromolecular binding of benzene was studied over a dose range spanning nine-orders of magnitude to determine the nature of the dose-response and to establish benzene's internal dosimetry at doses encompassing human environmental exposures. [14C]-Benzene was administered to B6C3F1 male mice at doses ranging between 700 pg/kg and 500 mg/kg body wt. Tissues, DNA and protein were analyzed for [14C]-benzene content between 0 and 48 h post-exposure (625 Ng/kg and 5… CONTINUE READING

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