Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

@article{Maher2005TissueDA,
  title={Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.},
  author={Jonathan M. Maher and Angela M Lucas Slitt and Nathan J Cherrington and Xingguo Cheng and Curtis D. Klaassen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 7},
  pages={947-55}
}
Analysis of the mouse genome has revealed eight multidrug resistance-associated (Mrp) transporters, with mouse homologs for all human MRPs except MRP8. Whereas MRP expression in tissues of humans and rats has been examined, no characterization exists for mice. Furthermore, the ontogeny of mouse Mrps is unknown, and such knowledge may be helpful in understanding age-related pharmacokinetics. Therefore, the purpose of this study was to quantitatively determine 1) expression of the Mrp family in… CONTINUE READING

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