Tissue distribution and functional expression of the human voltage-gated sodium channel β3 subunit

@article{Stevens2000TissueDA,
  title={Tissue distribution and functional expression of the human voltage-gated sodium channel β3 subunit},
  author={Edward B. Stevens and Peter J. Cox and Bhaval S. Shah and Alistair K. Dixon and Peter J. Richardson and Robert D. Pinnock and Kevin Y-S Lee},
  journal={Pfl{\"u}gers Archiv},
  year={2000},
  volume={441},
  pages={481-488}
}
This study investigated the distribution of β3 in human tissues and the functional effects of the human β3 subunit on the gating properties of brain and skeletal muscle α subunits. Using RT-PCR of human cDNA panels, β3 message was detected in brain, heart, kidney, lung, pancreas and skeletal muscle. Both αIIA and SkM1 expressed in Xenopus oocytes inactivated with a time course described by two exponential components representing fast and slow gating modes, while co-expression of human β3 with… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Functional analysis of the mouse Scn8a sodium channel.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1998

Functional analysis of the rat I sodium channel in xenopus oocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1998

Similar Papers

Loading similar papers…