Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase.

@article{Anderson1984TissueDA,
  title={Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase.},
  author={Karl Elmo Anderson and C S Simionatto and George S. Drummond and A. Kappas},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={228 2},
  pages={
          327-33
        }
}
Tin(Sn)-protoporphyrin is a potent competitive inhibitor of heme oxygenase and can also suppress naturally occurring or experimentally induced hyperbilirubinemia in animals. In this study we examined the plasma clearance of Sn-protoporphyrin, its persistence in tissues and the time course of heme oxygenase inhibition up to 7 days after administration of doses up to 50 mumol/kg b.w. to adult male rats. After s.c. doses the metalloporphyrin was rapidly and almost completely absorbed. Initial… CONTINUE READING

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