Tissue distribution and clearance of soluble murine TNF receptors in mice.

@article{Bemelmans1994TissueDA,
  title={Tissue distribution and clearance of soluble murine TNF receptors in mice.},
  author={Marc H. A. Bemelmans and Dirk. J. Gouma and Wim A. Buurman},
  journal={Cytokine},
  year={1994},
  volume={6 6},
  pages={608-15}
}
In this study, clearance of sTNFR was investigated. The data show that bilateral nephrectomy results in an increase of the levels of both sTNFR after which a new steady state situation develops, suggesting that other organs, apart from the kidneys, are involved in clearing of sTNFR. Bilateral nephrectomy also leads to an increase in circulating TNF. This TNF was detected by ELISA and appeared to be not biologically active. To investigate whether the endotoxin induced increase in sTNFR is… CONTINUE READING