Tissue distribution and chemical induction of multiple drug resistance genes in rats.

@article{Brady2002TissueDA,
  title={Tissue distribution and chemical induction of multiple drug resistance genes in rats.},
  author={James Brady and Nathan J Cherrington and Dylan P Hartley and Susan C N Buist and Ning Li and Curtis D. Klaassen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 7},
  pages={838-44}
}
Multiple drug resistance (mdr) genes encode P-glycoprotein, which is responsible for resistance to some cancer chemotherapeutic drugs and efflux of xenobiotics of cells. Thus, mdr can protect organs from xenobiotics. In rats, there are two mdr1 genes capable of xenobiotic transport, mdr1a and mdr1b. The purpose of this study was to determine the tissue distribution of rat mdr1a and mdr1b mRNA and whether microsomal enzyme inducers that increase phase I and II drug-metabolizing enzymes… CONTINUE READING