Tissue deposition of the insect repellent DEET and the sunscreen oxybenzone from repeated topical skin applications in rats.

@article{Fediuk2010TissueDO,
  title={Tissue deposition of the insect repellent DEET and the sunscreen oxybenzone from repeated topical skin applications in rats.},
  author={Daryl J. Fediuk and Tao Wang and Joshua E. Raizman and Fiona E Parkinson and Xiaochen Gu},
  journal={International journal of toxicology},
  year={2010},
  volume={29 6},
  pages={
          594-603
        }
}
Insect repellent N,N-diethyl-m-toluamide (DEET) and sunscreen oxybenzone are capable of enhancing skin permeation of each other when applied simultaneously. We carried out a cellular study in rat astrocytes and neurons to assess cell toxicity of DEET and oxybenzone and a 30-day study in Sprague-Dawley rats to characterize skin permeation and tissue disposition of the compounds. Cellular toxicity occurred at 1 µg/mL for neurons and 7-day treatment for astrocytes and neurons. DEET and oxybenzone… CONTINUE READING
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