Tissue culture methods to study neurological disorders: establishment of immortalized Schwann cells from murine disease models.

@article{Watabe2003TissueCM,
  title={Tissue culture methods to study neurological disorders: establishment of immortalized Schwann cells from murine disease models.},
  author={Kazuhiko Watabe and Tsuyoshi Sakamoto and Yoko Kawazoe and Makoto Michikawa and Katsuichi Miyamoto and Takashi Yamamura and Hideyuki Saya and Norie Araki},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2003},
  volume={23 1},
  pages={
          68-78
        }
}
Previously, the authors have established spontaneously immortalized cell lines from long-term cultures of normal adult mouse Schwann cells. Establishment of such Schwann cell lines derived from murine disease models may greatly facilitate studies of the cellular mechanisms of their peripheral nervous system lesions in the relevant diseases. Recently, the authors have established immortalized Schwann cell lines derived from Niemann-Pick disease type C mice (NPC; spm/spm) and globoid cell… CONTINUE READING
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