Tissue context-activated telomerase in human epidermis correlates with little age-dependent telomere loss.

@article{Krunic2009TissueCT,
  title={Tissue context-activated telomerase in human epidermis correlates with little age-dependent telomere loss.},
  author={Damir Krunic and Sharareh Moshir and Karin M. Greulich-Bode and Reynel Figueroa and Ana Cerezo and Hermann Stammer and Hillary Stark and Steven G Gray and Kirsten Vang Nielsen and Wolfgang Hartschuh and Petra Boukamp},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1792 4},
  pages={
          297-308
        }
}
Telomerase- and telomere length regulation in normal human tissues is still poorly understood. We show here that telomerase is expressed in the epidermis in situ independent of age but was repressed upon the passaging of keratinocytes in monolayer culture. However, when keratinocytes were grown in organotypic cultures (OTCs), telomerase was re-established, indicating that telomerase activity is not merely proliferation-associated but is regulated in a tissue context-dependent manner in human… CONTINUE READING
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