Tissue-based map of the human proteome

  title={Tissue-based map of the human proteome},
  author={M. Uhl{\'e}n and L. Fagerberg and B. Hallstr{\"o}m and C. Lindskog and P. Oksvold and A. Mardinoglu and {\AA}sa Sivertsson and C. Kampf and E. Sj{\"o}stedt and A. Asplund and Ingmarie Olsson and K. Edlund and E. Lundberg and Sanjay Navani and Cristina Al-Khalili Szigyarto and J. Odeberg and D. Djureinovic and Jenny Ottosson Takanen and S. Hober and T. Alm and P. Edqvist and Holger Berling and H. Tegel and J. Mulder and J. Rockberg and P. Nilsson and J. Schwenk and Marica Hamsten and Kalle von Feilitzen and Mattias Forsberg and L. Persson and Fredric Johansson and Martin Zwahlen and G. von Heijne and J. Nielsen and F. Pont{\'e}n},
  • M. Uhlén, L. Fagerberg, +33 authors F. Pontén
  • Published 2015
  • Biology, Medicine
  • Science
  • Protein expression across human tissues Sequencing the human genome gave new insights into human biology and disease. However, the ultimate goal is to understand the dynamic expression of each of the approximately 20,000 protein-coding genes and the function of each protein. Uhlén et al. now present a map of protein expression across 32 human tissues. They not only measured expression at an RNA level, but also used antibody profiling to precisely localize the corresponding proteins. An… CONTINUE READING

    Topics from this paper.

    GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
    • 1,660
    • Highly Influenced
    • PDF
    A pathology atlas of the human cancer transcriptome
    • 820
    • PDF
    Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants
    • 393
    • PDF
    On the Dependency of Cellular Protein Levels on mRNA Abundance
    • 823
    UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses1
    • 749
    MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
    • 705
    • PDF
    Mass-spectrometric exploration of proteome structure and function
    • 683
    • PDF


    Publications referenced by this paper.
    An Integrated Encyclopedia of DNA Elements in the Human Genome
    • 8,298
    • PDF
    TopHat: discovering splice junctions with RNA-Seq
    • 9,627
    • PDF
    A draft map of the human proteome
    • 1,427
    • PDF
    Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • 4,559
    • PDF
    Towards a proteome-scale map of the human protein–protein interaction network
    • 2,642
    • PDF
    Mass-spectrometry-based draft of the human proteome
    • 1,304
    • Highly Influential
    • PDF
    Comprehensive Molecular Characterization of Human Colon and Rectal Cancer
    • 3,949
    • PDF