Tissue-based class control: the other side of tolerance

@article{Matzinger2011TissuebasedCC,
  title={Tissue-based class control: the other side of tolerance},
  author={Polly Matzinger and Tirumalai Kamala},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={221-230}
}
In this Essay, we offer a new perspective on how immune responses are regulated. We do not cover how they are turned on and off, but focus instead on the second major aspect of an immune response: the control of effector class. Although it is generally thought that the class of an immune response is tailored to fit the invading pathogen, we suggest here that it is primarily tailored to fit the tissue in which the response occurs. To this end, we cover such topics as the nature of T helper (TH… 
The Ambiguity in Immunology
TLDR
In this review, various immunological tactics including: (a) the opposing functions driving immune responses, immune-regulation, and contra-regulation as well as the phenomenon of chronic immune activation as a result of a continuous cross-presentation of apoptotic T cells by dendritic cells are considered.
On Analyzing How the Th1/Th2 Phenotype of an Immune Response Is Determined: Classical Observations Must Not Be Ignored
TLDR
It is argued that the prevalent, contemporary conceptual frameworks, employed to analyze the nature of the decision criterion controlling the Th1/Th2 phenotype of the immune response, are implausible, as they ignore pertinent, classical observations.
Immune class regulation as an integrated response of factors related to host, stimulus and context
  • P. Ss
  • Biology, Medicine
    Scandinavian journal of immunology
  • 2018
TLDR
It is proposed that the immune class regulation can be considered as a result of the interactions between factors related to host, stimulus and the context.
Meanderings into the Regulation of Effector Class by the Immune System: Derivation of the Trauma Model
  • M. Cohn
  • Biology, Medicine
    Scandinavian journal of immunology
  • 2012
TLDR
This essay is an attempt to define the elements required for an understanding of Module 3, the regulation of effector class, and that leads the Trauma Model.
Immune regulatory function of B cells.
TLDR
The factors that are important for Breg differentiation and for their effector function in both mouse and human are discussed.
Immune Balance: The Development of the Idea and Its Applications
  • B. Swiatczak
  • Biology, Medicine
    Journal of the history of biology
  • 2014
TLDR
Advances in mucosal immunology confirm that instead of distinguishing between self and foreign the immune system reacts to microbial, chemical and self-induced alterations to produce responses that counterbalance effects of these changes.
Crossroads between immune responses and physiological regulation: Metabolic control of resistance versus tolerance against disease
TLDR
A number of recent publications are reviewed that have begun to shed light on the physiological and immunological mechanisms that coordinate host defense and metabolic processes and will cover the areas of energetic control, substrates utilization, and the regulatory signals that promote infectious disease tolerance.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 156 REFERENCES
Regional immunity and immune privilege.
TLDR
The immune system is confronted with an endless array of potential pathogens and immunogens and it must make a decision regarding the nature of the response that is invoked, which amounts to a compromise in which immunemediated inflammation is restrained or diverted in a manner that inflicts minimal injury to host cells.
Ocular autoimmunity: the price of privilege?
  • R. Caspi
  • Biology, Medicine
    Immunological reviews
  • 2006
TLDR
The case shall be made that although immune privilege protects vision by keeping the immune system at bay, a potential for developing destructive anti‐retinal autoimmunity may be the price for the day‐to‐day protection afforded by immune privilege against inflammatory insults.
A vision of cell death: Fas ligand and immune privilege 10 years later
TLDR
The original evidence for the role of FasL in immune privilege is reexamine, progress is updated, and some of the issues that remain unresolved are discussed.
Antigen-specific T-T interactions regulate CD4 T-cell expansion.
TLDR
It is found that CD4 T cells establish a negative feedback loop by capturing their cognate major histocompatibility class (MHC)/peptide complexes from Ag-presenting cells and presenting them to Ag-experienced CD4T cells, thereby inhibiting their recruitment into the response while allowing recruitment of naive T cells.
The testis in immune privilege
TLDR
The role of androgens in testicular immune regulation has long been underestimated; yet, accumulating evidence now shows that they orchestrate the inhibition of proinflammatory cytokine expression and shift cytokine balance toward a tolerogenic environment.
The Role of Dendritic Cells, B Cells, and M Cells in Gut-Oriented Immune Responses
TLDR
The results suggest that systemic immune responses to soluble oral Ags do not require an organized gut-associated lymphoid tissue but are most likely induced by gut-conditioned dendritic cells that function both to initiate the gut-oriented response and to impart the characteristic features that discriminate it from responses induced parenterally.
Perspectives on Mucosal Vaccines: Is Mucosal Tolerance a Barrier?1
TLDR
Optimization of mucosal vaccination strategies has the potential for enhancing protective immune responses and suppressing systemic responses to autoantigens desirable for the treatment of autoimmune diseases.
Modulation of Dendritic Cell Responses by Parasites: A Common Strategy to Survive
TLDR
This review will focus on the strategies protozoan and helminth parasites have developed to interfere with dendritic cell activities as well as in the possible mechanisms involved.
Viral subversion of the immune system.
TLDR
A review of the diverse array of pathways and molecular targets used by viruses to elude immune detection and destruction describes the continuous interactions between host and pathogens during their coevolution.
Sensing Pathogens and Tuning Immune Responses
TLDR
A model is constructed in which the type of immune response to an infection is viewed as a function of several determinants, including the subpopulation of DCs, the nature of the microbe, microbe recognition receptors, and the cytokine microenvironment.
...
1
2
3
4
5
...