Tissue-aware data integration approach for the inference of pathway interactions in metazoan organisms

@article{Park2015TissueawareDI,
  title={Tissue-aware data integration approach for the inference of pathway interactions in metazoan organisms},
  author={Christopher Y. Park and Arjun Krishnan and Qian Zhu and Aaron K. Wong and Young-suk Lee and Olga G. Troyanskaya},
  journal={Bioinformatics},
  year={2015},
  volume={31 7},
  pages={1093-101}
}
MOTIVATION Leveraging the large compendium of genomic data to predict biomedical pathways and specific mechanisms of protein interactions genome-wide in metazoan organisms has been challenging. In contrast to unicellular organisms, biological and technical variation originating from diverse tissues and cell-lineages is often the largest source of variation in metazoan data compendia. Therefore, a new computational strategy accounting for the tissue heterogeneity in the functional genomic data… CONTINUE READING
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