Tissue- and site-specific DNA recombination in transgenic mice.

  title={Tissue- and site-specific DNA recombination in transgenic mice.},
  author={Paul C. Orban and D K C Chui and Jamey D Marth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 15},
We have developed a method of specifically modifying the mammalian genome in vivo. This procedure comprises heritable tissue-specific and site-specific DNA recombination as a function of recombinase expression in transgenic mice. Transgenes encoding the bacteriophage P1 Cre recombinase and the loxP-flanked beta-galactosidase gene were used to generate transgenic mice. Genomic DNA from doubly transgenic mice exhibited tissue-specific DNA recombination as a result of Cre expression. Further… CONTINUE READING
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