Tissue and serum concentrations of levofloxacin in orthopaedic patients.

  title={Tissue and serum concentrations of levofloxacin in orthopaedic patients.},
  author={Heike von Baum and Stefan Boettcher and Regina A Abel and Hans Juergen Gerner and Hans G{\"u}nter Sonntag},
  journal={International journal of antimicrobial agents},
  volume={18 4},
The level of levofloxacin was determined in serum, bone and several tissues after a single dose of 500 mg i.v. Twenty-one patients (mean age: 56.8 years) undergoing bone surgery (nine patients) or surgical debridement of a decubitus ulcer (12 patients) who received levofloxacin as perioperative prophylaxis were included in the study. During surgery, blood and tissue samples were obtained approximately 1.5 h (range 40-210 min) postdosing. Levofloxacin concentrations in 87 specimens including 21… CONTINUE READING

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