Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.

  title={Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.},
  author={Hak Soo Choi and Binil Itty Ipe and Preeti Misra and Jeong Heon Lee and Moungi G Bawendi and John V. Frangioni},
  journal={Nano letters},
  volume={9 6},
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance… CONTINUE READING

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