Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding.

@article{Qu1999TissueAI,
  title={Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding.},
  author={Xianqin Qu and J. Paul Seale and R. B. Donnelly},
  journal={The Journal of endocrinology},
  year={1999},
  volume={162 2},
  pages={
          207-14
        }
}
The mechanisms of insulin resistance in the obese Zucker rat have not been clearly established but increased diacylglycerol-protein kinase C (DAG-PKC) signalling has been associated with decreased glucose utilisation in states of insulin resistance and non-insulin-dependent diabetes mellitus. The purpose of this study was to characterise tissue- and isoform-selective differences in DAG-PKC signalling in insulin-sensitive tissues from obese Zucker rats, and to assess the effects of feeding on… CONTINUE READING

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