Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice.

@article{Buckley2007TissueAG,
  title={Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice.},
  author={David B. Buckley and Curtis D. Klaassen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 1},
  pages={121-7}
}
UDP-glucuronosyltransferases (UGTs) catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. Currently, little information regarding tissue- or gender-specific expression of mouse UGTs is available. Mice are increasingly popular models in biomedical research, and therefore, thorough characterization of murine drug metabolism is desired. The purpose of the present study was to determine… CONTINUE READING
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Glucuronidation of Drugs and Other Compounds, pp 3–78

  • GJ Dutton
  • 1980
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