Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.

@article{Martines2015TissueAC,
  title={Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.},
  author={Roosecelis Brasil Martines and Dianna L Ng and Patricia W. Greer and Pierre E. Rollin and Sherif R. Zaki},
  journal={The Journal of pathology},
  year={2015},
  volume={235 2},
  pages={153-74}
}
Ebola viruses and Marburg viruses include some of the most virulent and fatal pathogens known to humans. These viruses cause severe haemorrhagic fevers, with case fatality rates in the range 25-90%. The diagnosis of filovirus using formalin-fixed tissues from fatal cases poses a significant challenge. The most characteristic histopathological findings are seen in the liver; however, the findings overlap with many other viral and non-viral haemorrhagic diseases. The need to distinguish filovirus… CONTINUE READING
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