Tissue and blood concentrations of chloroquine following chronic administration in the rat

@article{Adelusi1982TissueAB,
  title={Tissue and blood concentrations of chloroquine following chronic administration in the rat},
  author={S. A. Adelusi and L. Salako},
  journal={Journal of Pharmacy and Pharmacology},
  year={1982},
  volume={34}
}
  • S. A. Adelusi, L. Salako
  • Published 1982
  • Medicine
  • Journal of Pharmacy and Pharmacology
    • The antimalarial drug, chloroquine, is extensively distributed in tissue and slowly eliminated such that after a single dose, a plasma half-life of 3-5 days has been found (McChesney & McAuliff 1961; McChesney et al 1967). A peak tissue/plasma concentration ratio greater than 300 is obtained in many tissues and after a single dose the drug can be found in the liver and urine for up to five years (Gaudette & Coatney 1961; Rubin et al 1963; Zvaifler et al 1963). Chronic administration of… CONTINUE READING
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    References

    SHOWING 1-10 OF 12 REFERENCES
    The metabolism of chloroquine in man during and after repeated oral dosage.
    • 79
    STUDIES ON THE PHARMACOLOGY OF CHLOROQUINE. RECOMMENDATIONS FOR THE TREATMENT OF CHLOROQUINE RETINOPATHY.
    • 72
    Metabolism of chloroquine and hydroxychloroquine in albino and pigmented rats.
    • 51
    Chloroquine serum concentration and side effects: Evidence for dose‐dependent kinetics
    • 105
    Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine.
    • 92
    The concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and 'double' dosage in non-immunes: clinical implications.
    • 19
    Treatment of Rheumatoid Arthritis with Chloroquine
    • 11
    Improved fluorimetrie assay of chloroquine in biological samples
    • 41
    Aortitis and aortic insufficiency in the chronic rheumatic disorders--a reappraisal.
    • 53
    A possible mechanism of prolonged antimalarial activity.
    • 2