Tissue and blood concentrations of chloroquine following chronic administration in the rat

@article{Adelusi1982TissueAB,
  title={Tissue and blood concentrations of chloroquine following chronic administration in the rat},
  author={S. A. Adelusi and L. Salako},
  journal={Journal of Pharmacy and Pharmacology},
  year={1982},
  volume={34}
}
  • S. A. Adelusi, L. Salako
  • Published 1982
  • Medicine
  • Journal of Pharmacy and Pharmacology
  • The antimalarial drug, chloroquine, is extensively distributed in tissue and slowly eliminated such that after a single dose, a plasma half-life of 3-5 days has been found (McChesney & McAuliff 1961; McChesney et al 1967). A peak tissue/plasma concentration ratio greater than 300 is obtained in many tissues and after a single dose the drug can be found in the liver and urine for up to five years (Gaudette & Coatney 1961; Rubin et al 1963; Zvaifler et al 1963). Chronic administration of… CONTINUE READING
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