Tissue and blood concentrations of chloroquine following chronic administration in the rat
@article{Adelusi1982TissueAB, title={Tissue and blood concentrations of chloroquine following chronic administration in the rat}, author={S. A. Adelusi and L. Salako}, journal={Journal of Pharmacy and Pharmacology}, year={1982}, volume={34} }
The antimalarial drug, chloroquine, is extensively distributed in tissue and slowly eliminated such that after a single dose, a plasma half-life of 3-5 days has been found (McChesney & McAuliff 1961; McChesney et al 1967). A peak tissue/plasma concentration ratio greater than 300 is obtained in many tissues and after a single dose the drug can be found in the liver and urine for up to five years (Gaudette & Coatney 1961; Rubin et al 1963; Zvaifler et al 1963). Chronic administration of… CONTINUE READING
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