Tissue and T cell distribution of precursor and mature IL-16.

  title={Tissue and T cell distribution of precursor and mature IL-16.},
  author={Geoffrey L. Chupp and E. Allen Wright and Dianqing Wu and Margaret Vallen-Mashikian and William W. Cruikshank and David M. Center and Hardy Kornfeld and Jeffrey S. Berman},
  journal={Journal of immunology},
  volume={161 6},
IL-16 is a novel cytokine, which is chemoattractant for CD4+ T cells, macrophages, and eosinophils. Recently, it was reported that IL-16 is synthesized as an approximately 80-kDa precursor molecule, pro-IL-16. Since little is known about the processing and tissue distribution of IL-16 and pro-IL-16, we investigated the distribution of IL-16 mRNA and protein in human lymphoid tissue. Northern blotting identified IL-16 mRNA predominantly in normal lymphoid organs, including PBMC, spleen, and… CONTINUE READING
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