Tissue and Process Specific microRNA–mRNA Co-Expression in Mammalian Development and Malignancy

@article{Liu2009TissueAP,
  title={Tissue and Process Specific microRNA–mRNA Co-Expression in Mammalian Development and Malignancy},
  author={Hongye Liu and Issac S. Kohane},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={396 - 400}
}
An association between enrichment and depletion of microRNA (miRNA) binding sites, 3' UTR length, and mRNA expression has been demonstrated in various developing tissues and tissues from different mature organs; but functional, context-dependent miRNA regulations have yet to be elucidated. Towards that goal, we examined miRNA-mRNA interactions by measuring miRNA and mRNA in the same tissue during development and also in malignant conditions. We identified significant miRNA-mediated biological… CONTINUE READING

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