Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: Implications for local drug delivery

@article{Saito2006TissueAO,
  title={Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: Implications for local drug delivery},
  author={Ryuta Saito and Michal T. Krauze and Charles O. Noble and Matyas Tamas and Krystof S. Bankiewicz},
  journal={Journal of Neuroscience Methods},
  year={2006},
  volume={154},
  pages={225-232}
}
Convection-enhanced delivery (CED) is a recently developed technique for local delivery of agents to a large volume of tissue in the central nervous system (CNS). We have previously reported that this technique can be applied to CNS delivery of nanoparticles including viruses and liposomes. In this paper, we describe the impact of key physical and chemical properties of infused molecules on the extent of CED-mediated delivery. For simple infusates, CED distribution was significantly increased… CONTINUE READING

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