Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

@article{Sujino2016TissueAO,
  title={Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation},
  author={Tomohisa Sujino and Mariya London and David P. Hoytema van Konijnenburg and Tomiko Rendon and Thorsten Buch and Hernandez Moura Silva and Juan Jose Lafaille and Bernardo S Reis and Daniel Mucida},
  journal={Science},
  year={2016},
  volume={352},
  pages={1581-1586}
}
Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting inflammatory responses to nonself antigens. Within the intestine, pTregs are located primarily in the lamina propria, whereas intraepithelial CD4+ T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs. Upon migration to the epithelium… CONTINUE READING
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