Tissue accumulation of lanthanum as compared to aluminum in rats with chronic renal failure--possible harmful effects after long-term exposure.

@article{Nikolov2010TissueAO,
  title={Tissue accumulation of lanthanum as compared to aluminum in rats with chronic renal failure--possible harmful effects after long-term exposure.},
  author={Igor G. Nikolov and Nobuhiko Joki and St{\'e}phanie Vicca and Natacha Patey and Daniel Auch{\`e}re and Joyce Benchitrit and Jean-Pierre Flinois and Marianne Ziol and Philippe Beaune and Tilman Bernhard Dr{\"u}eke and Bernard Lacour},
  journal={Nephron. Experimental nephrology},
  year={2010},
  volume={115 4},
  pages={
          e112-21
        }
}
BACKGROUND Lanthanum (La) carbonate is a new treatment for hyperphosphatemia. We tested the effects of oral La carbonate and aluminum hydroxide, respectively, on tissue accumulation and liver function in rats with chronic renal failure (CRF). METHODS Adult male non-CRF and CRF rats were randomly assigned to 3 groups receiving either standard diet (St.D), or the same diet supplemented with 3% La carbonate (non-CRF La vs. CRF La) or 3% aluminum hydroxide (non-CRF Al vs. CRF Al). RESULTS After… CONTINUE READING