Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes.

@article{Zhang2010TissueTO,
  title={Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes.},
  author={Lei Zhang and Fang Qi and Giovanni Gaudino and Oriana Strianese and Haining Yang and Paul Ian Morris and Harvey I. Pass and Vivek R. Nerurkar and Maurizio Bocchetta and Michele Carbone},
  journal={Genes & cancer},
  year={2010},
  volume={1 10},
  pages={1008-20}
}
SV40 has been detected prevalently in a limited panel of human tumors: mesothelioma, bone and brain tumors, and lymphoma. These are the same tumor types that are specifically induced by SV40 when injected into hamsters, a finding that has raised concerns about the possible pathogenic role of SV40 in humans. Two different SV40 isolates differing in the number of 72-bp elements in the virus regulatory region, archetypal SV40 (1ESV40), which contains one 72 bp, and nonarchetypal SV40 (wtSV40… CONTINUE READING