Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells.

@article{Pang2016TissueSA,
  title={Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells.},
  author={Mei-Fong Pang and Michael J. Siedlik and Siyang Han and Melody Lee Stallings-Mann and Derek C. Radisky and Celeste M. Nelson},
  journal={Cancer research},
  year={2016},
  volume={76 18},
  pages={
          5277-87
        }
}
Breast tumors are stiffer and more hypoxic than nonmalignant breast tissue. Here we report that stiff and hypoxic microenvironments promote the development of breast cancer stem-like cells (CSC) through modulation of the integrin-linked kinase ILK. Depleting ILK blocked stiffness and hypoxia-dependent acquisition of CSC marker expression and behavior, whereas ectopic expression of ILK stimulated CSC development under softer or normoxic conditions. Stiff microenvironments also promoted tumor… CONTINUE READING
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ChenCS. A novel HIF-1alphaintegrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1alpha expression and epithelial-mesenchymal transition in cancer cells

  • ChouCC, ChuangHC, SB Salunke, SK Kulp
  • Oncotarget
  • 2015
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