Tissue Inhibitor of Metalloproteinases-1 Stimulates Gene Expression in MDA-MB-435 Human Breast Cancer Cells by Means of its Ability to Inhibit Metalloproteinases

@article{Porter2005TissueIO,
  title={Tissue Inhibitor of Metalloproteinases-1 Stimulates Gene Expression in MDA-MB-435 Human Breast Cancer Cells by Means of its Ability to Inhibit Metalloproteinases},
  author={Joseph F. Porter and Shashi Sharma and Donna L. Wilson and Maya Kappil and Ronald P. Hart and David T. Denhardt},
  journal={Breast Cancer Research and Treatment},
  year={2005},
  volume={94},
  pages={185-193}
}
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of metalloproteinases (MPs). Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis. TIMP-1 can also stimulate proliferation ([3H]thymidine incorporation) and cellular anabolic processes (Alamar Blue… CONTINUE READING
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Characterization of the metabolic stimulation caused by tissue inhibitor of metalloproteinases-1 on human breast cancer cells

  • JF Porter
  • Doctoral Dissertation, Rutgers University,
  • 2004
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