Tissue IGF-I Measured by Microdialysis Reflects Body Glucose Utilization After rhIGF-I Injection in Type 1 Diabetes.

@article{Ekstrm2015TissueIM,
  title={Tissue IGF-I Measured by Microdialysis Reflects Body Glucose Utilization After rhIGF-I Injection in Type 1 Diabetes.},
  author={Klas Ekstr{\"o}m and Mari-Anne Pulkkinen and Christine Carlsson-Skwirut and Anna-Lena Brorsson and Zhulin Ma and Jan Frystyk and Peter Bang},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2015},
  volume={100 11},
  pages={4299-306}
}
CONTEXT Type 1 diabetes is associated with portal insulin deficiency and disturbances in the GH-IGF axis including low circulating IGF-I and GH hypersecretion. Whether peripheral hyperinsulinemia and GH hypersecretion, which are relevant to the development of vascular complications, result in elevated tissue IGF-I remains unknown. OBJECTIVE The purpose of this study was to determine the relationship between whole-body glucose uptake and tissue IGF-I measured by microdialysis. DESIGN This… CONTINUE READING