Tissue Factor and Cancer Metastasis: The Role of Intracellular and Extracellular Signaling Pathways

@article{Versteeg2004TissueFA,
  title={Tissue Factor and Cancer Metastasis: The Role of Intracellular and Extracellular Signaling Pathways},
  author={Henri H Versteeg and C. Arnold Spek and Maikel Petrus Peppelenbosch and Dick J. Richel},
  journal={Molecular Medicine},
  year={2004},
  volume={10},
  pages={6-11}
}
Tissue factor (TF) initiates the coagulation cascade but also plays a role in cancer and metastasis. This transmembrane protein is frequently upregulated on tumor cells and cells that show metastatic behavior. Furthermore, it is a significant risk factor for hepatic metastasis in patients suffering from colon cancer. Recently, it has been shown that TF, together with its natural ligand factor VIIa, induces intracellular changes, such as signal transduction cascades, gene transcription, and… CONTINUE READING
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