Tissue Factor Residues That Putatively Interact with Membrane Phospholipids

@inproceedings{Ke2014TissueFR,
  title={Tissue Factor Residues That Putatively Interact with Membrane Phospholipids},
  author={Ke Ke and Jian Yuan and James H Morrissey},
  booktitle={PloS one},
  year={2014}
}
Blood clotting is initiated by the two-subunit enzyme consisting of the plasma protease, factor VIIa (the catalytic subunit), bound to the integral membrane protein, tissue factor (the regulatory subunit). Molecular dynamics simulations have predicted that certain residues in the tissue factor ectodomain interact with phosphatidylserine headgroups to ensure optimal positioning of the tissue factor/factor VIIa complex relative to its membrane-bound protein substrates, factors IX and X. In this… CONTINUE READING