Tissue Engineering of Vein Valves Based on Decellularized Natural Matrices.

@article{Mogaldea2017TissueEO,
  title={Tissue Engineering of Vein Valves Based on Decellularized Natural Matrices.},
  author={Alexandru Mogaldea and Tobias Goecke and Karolina Theodoridis and Axel Haverich and Serghei Cebotari and Andres Hilfiker},
  journal={Cells, tissues, organs},
  year={2017},
  volume={204 3-4},
  pages={
          199-209
        }
}
Valvular repair or transplantation, designed to restore the venous valve function of the legs, has been proposed as treatment in chronic venous insufficiency. Available grafts or surgeries have provided limited durability so far. Generating venous valve substitutes by means of tissue engineering could be a solution. We generated decellularized jugular ovine vein conduits containing valves (oVVC) after reseeding with ovine endothelial cells differentiated from peripheral blood-derived… CONTINUE READING

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