Tissue Engineering at the Micro-Scale

@article{Bhatia1999TissueEA,
  title={Tissue Engineering at the Micro-Scale},
  author={Sangeeta N. Bhatia and Christopher S. Chen},
  journal={Biomedical Microdevices},
  year={1999},
  volume={2},
  pages={131-144}
}
The possibility to replace damaged or diseased organs with artificial tissues engineered from a combination of living cells and biocompatible scaffolds is becoming a reality through multi-disciplinary efforts. A number of critical components within this effort are being facilitated by microfabrication and MEMS approaches, including research tools to elucidate mechanisms which control cellular behavior as well as development of methods to manufacture cellular scaffolds at ever higher resolutions… 
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162 Citations
Background Citations
26
Methods Citations
6

162 Citations

Fabrication of three-dimensional tissues.
TLDR
This chapter reviews three-dimensional fabrication techniques for tissue engineering, including: acellular scaffolds, cellular assembly, and hybrid scaffold/cell constructs.
Microfabrication Technology in Tissue Engineering
Microscale technologies for tissue engineering and biology.
TLDR
An overview of the use of microfluidics, surface patterning, and patterned cocultures in regulating various aspects of cellular microenvironment is discussed, as well as the application of these technologies in directing cell fate and elucidating the underlying biology.
Microfabrication of three-dimensional engineered scaffolds.
TLDR
A brief overview of the fundamental microfabrication technologies used for tissue engineering will be presented, along with a summary of progress in a number of applications, including the liver and kidney.
Computer Aided Tissue Engineering from Modeling to Manufacturing
TLDR
Tissue engineering is an interdisciplinary field that applies the principles and methods of bioengineering, material science, and life sciences toward the assembly of biologic substitutes that will restore, maintain, and improve tissue functions following damage either by disease or traumatic processes.
Micro- and Nanoscale Control of Cellular Environment for Tissue Engineering
TLDR
This chapter analyzes the use of microand nanoscale engineering techniques for controlling and studying cell–cell, cell–substrate and cell–soluble factor interactions, as well as for fabricating organs with controlled architecture and resolution.
Combined technologies for microfabricating elastomeric cardiac tissue engineering scaffolds.
TLDR
This work combined micromolding and microablation technologies to create muscle tissue engineering scaffolds from the biodegradable elastomer poly(glycerol sebacate), which exhibited well defined surface patterns and pores and robust elastomersic tensile mechanical properties.
A Review of Three-Dimensional Printing in Tissue Engineering.
TLDR
An overview of current 3D printing techniques used in tissue engineering is provided with an emphasis on the printing mechanism and the resultant scaffold characteristics.
Biomimetic Design of Artificial Micro-vasculatures for Tissue Engineering
TLDR
An overview of microfluidic tissue constructs is provided, and the hydrodynamic scaling laws that underpin the fluid mechanics of vascular systems are reviewed, and it is shown that it is possible to introduce precise control over the shear stress or residence time in a hierarchical network, in order to aid cell adhesion and enhance the diffusion of nutrients and waste products.
Design and Development of Three-Dimensional Scaffolds for Tissue Engineering
TLDR
There is an emerging scaffold fabricating technique using solid free form fabrication (SFF) that has shown to be highly effective in integrating structural architecture with changes in surface chemistry of the scaffolds, and integration of growth factors.
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References

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TLDR
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